Targeted cell typing that relies on existing single-cell data gives incomplete and biased maps, which can hide the molecular and cellular diversity of a tissue section. Here, spage2vec, a de novo approach, spatially resolves and characterizes the cellular diversity during human heart development. The viewer shows the data of the in situ sequencing experiment and the identified cell types.
Open the human heart in TissUUmaps 3.
Publication: R. S. Marco Salas, X. Yuan, C. Sylvén, M. Nilsson, C. Wählby and G. Partel. De novo spatiotemporal modelling of cell-type signatures identifies novel cell populations in the developmental human heart. PLOS Computational Biology, 2022. doi:10.1371/journal.pcbi.1010366